1. Doomed to destruction or misery:

The city shall be accursed. John 6.

2. Separated from the faithful; cast out of the church; excommunicated.

I could wish myself accursed from Christ.

3. Worthy of the curse; detestable; execrable.

Keep from the accursed thing. Josh 6.

Hence,

4. Wicked; malignant in the extreme.